Computer-generated melodies from human neurons, based on electrical recordings of brain activity during wakefulness or sleep. A dataset of 92 neurons was used - these neurons were simultaneously recorded in the temporal cortex of human subjects (Peyrache et al., Proc. Natl. Acad. Sci. USA, 2012). A given neuron was associated to a fixed tone, and every time this neuron fires, a note is emitted. The "melody" produced gives an idea about the distributed firing activity of those neurons. The files were converted in MP3 from MIDI; "sleeping" means slow-wave sleep (deep sleep), "REM" means "rapid-eye movement sleep" (where most dreams occur). Two instruments are present, a woodblock for excitatory neurons and a xylophone for inhibitory cells. From these melodies, one can hear that the distributed firing activity is almost identical during dreaming compared to wakefulness, which emphasizes the high similarity between these two different brain states. (Author: Alain Destexhe, CNRS, France; data obtained in collaboration with University of California San Diego and Harvard Medical School, USA)
In the more recently-added epileptic seizure file, the activity starts with normal "Wake" activity, following by an epileptic (focal) seizure, which can be heard very well while listening to that melody.